ea0084ps3-12-107 | Graves’ Disease 2 and Orbitopathy | ETA2022
Gortz Gina-Eva
, Eckstein Anja
, Jesenek Christoph
, Horstmann Mareike
, Philipp Svenja
, Bruderek Kirsten
, Oeverhaus Michael
, Daser Anke
, Bechrakis Nikolaos
, Brandau Sven
, Berchner-Pfannschmidt Utta
Introduction: The inflammatory eye disease Graves orbitopathy (GO) is the main complication of Graves disease in patients. In previous studies we have shown that hypoxia and HIF-1 dependent pathways could play an important role in the pathogenic process of GO. Hypoxia is known to attract inflammatory cells and therefore maintains inflammation and recruitment of immune cells like macrophages (MQ). However, few is known about the specific contribution of MQ to the pr...